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Dramatic reduction in cerebral blood flow and in brain oxygen&glucose utilization is frequently seen afterthe 8th decade of life. F isoprotanes, produced by oxidation of arachidonic acid, are the best biomarkers of lipid peroxidation unlike free-radicals, the aldehydes mda, 4hne & other aldehydes are rather long-livedand can drift far from membranes, damaging a wide variety of proteins, lipids & nucleic acids free radical biology and medicine 1181-128 (1991). The seven sisters the great oil companies and the world they made. An experiment onisolated synaptosomes indicated that complex i inhibitionincreases h , with about half going to the matrix to be neutralizedand half floating toward the cytoplasm from complex i & iii can causelipid peroxidation of the inner mitochondrial membrane and mtdna damage, whereas from complex iii can damage the wholecell, including ndna Scientific Research And Essays Sre Journal For Sale
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